Blog posts tagged with 'disease'

Sinking Teeth Into The Mysteries of Plague

Two plague victims in Aschheim-Bajuwarenring cemetery in Bavaria, Germany who died some 1500 years ago have been unearthed and are able to help provide an international team of scientists with a better understanding the type of virus that was responsible for their deaths sometime between 541 and 543. Thanks to the dental remains of these two unearthed plague victims, researchers using very sophisticated methods were able to extract DNA fragments of plague from the teeth from the skeletal remains and reconstruct the genome of what is now the oldest pathogen obtained to date. Yersinia Pestis or Y. Pestis is also known as plague. This bacterium was found to be responsible for the Justinian outbreak and the results showed that this was unique and distinct from various other strains that would later become the Black Death and other plague pandemics that would follow.

“This study raises intriguing questions about why a pathogen that was both so successful and so deadly suddenly died out. One testable possibility is that human populations evolved to become less susceptible,” says Edward Holmes, an NHMRC Australia Fellow at the University of Sydney.

Up until now little has been known about the exact cause of the Justinian epidemic’s origins or cause. The Justinian plague is thought to have been instrumental in bringing about the end of the Roman Empire and was, until the recent findings were too discover, responsible for the Black Death. The Justinian Plague is believed to have killed 30 to 50 million people, estimated to have been at least half of the world’s population at that time. Later the Black Death would emerge to ravage the medieval population killing 50 million Europeans between 1347 and 1351 some 800 years later. These recent findings now show that the Justinian plague was a unrelated strain from the plague that caused the Black Death.

The new results that are published in online edition of The Lancet Infectious Disease, show that the Justinian Plague was a distinct and separate genome of the same Pathogen know as Yersinia Pestis and not an evolutionary forefather or related to the same Yersinia Pestis strains responsible for the Black Death. Another pandemic that had taken hold in Hong Kong and spread across the globe is now more likely to be considered the precursor to the Black Death.

These findings would suggest that the Justinian pandemic strain also originated in Asia and not in Africa as some scientist originally thought. This would lead them to theorize that earlier epidemics, such as the Plague of Athens (430 BC) and the Antoine Plague (165 – 180 AD) may have also been unique and distinct emergence of related Yersinia Pestis strains.

“We know the bacterium Y. Pestis has jumped from rodents into humans throughout history and rodent reservoirs of plague still exist today in many parts of the world. If the Justinian plague could erupt in the human population, cause a massive pandemic, and then die out, it suggest it could happen again. Fortunately we now have antibiotics that could be used to effectively treat plague, which lessens the chances of another large scale human pandemic” says Dave Wagner, an associate professor in the Center for Microbial Genetics and Genomics at Northern Arizona University.

These studies would suggest that the threat of an outbreak of Yersinia Pestis can occur at any time now, or in the future, is quite possible. Add to this, the possibility of some individual or person intent to using the pathogen as a weapon to wreck terror on an unsuspecting population raises the stakes even higher. New technologies are now available to health and safety teams in the early detection of such possible natural outbreaks and first responders now have the capabilities to be able to equip themselves with the latest tools required to easily and reliably detect not only Yersinia Pestis, but other possible pathogens that could be used as weapons against humanity. This ability to provide early detection is essential in containing and maintaining control of a terrorist planned outbreak and is crucial to preventing another full scale global population pandemic such as those seen in the past.

One of the biggest breakthroughs in rapid and reliable early detection of pathogens that can be utilized against terrorist is the BADD line of bio-warfare detection tests produced by AdVnt Biotechnologies LLC. Developed in response to the white powder incidents that occurred after 9/11, the tests were used in the detection of bio-warfare pathogens during the Iraq War. This line of tests gave first responders the ability to arrive at a possible bio-threat scene and test for powders and liquids left by suspected terrorist and ascertain within 15-minutes or less if the material held the potential of becoming a cause of wide spread contamination. This rapid testing with their on-the-scene detection capabilities helped to open windows of opportunities for immediate containment and control of a possible pandemic. AdVnt Biotechnologies was also the first to revolutionize the hand held assays when they were the first to develop a testing platform that allows for the collection of one suspicious sample of unknown origin to be tested against multiple targets on one detection test cassette. In the not too distant past, responders would have to collect up to 5 samples and run 5 tests one at a time to discover what active agent provided the danger of contamination. If there was very little or sparse material left behind, the residue would have to be sent off site to be examined while the clock was ticking. With the invention of AdVnt Biotechnologies ground breaking PS-5T Pro-Strip multi-agent rapid screening system, for the first time, responders have the ability to hit five different targets from one collected bio-threat sample. Saving time, saving resources, saving lives.

Return of the Black Death

It may sound like a campy title to a old Hammer Film Horror Movie but unfortunately it’s real and it’s more common then you may think.

According to a article posted by Reuters on July 25, a Squirrel was found at the Angeles National Forest in California that was infected with the Plague. This has been the sixth squirrel located in Southern California’s San Gabriel Mountains since 1995 to test positive for the disease.

Authorities have shut down the park for at least a week while they have a chance to dust the burrows for fleas, which carry the bacteria and test more squirrels in the area. The most recent squirrel was trapped on July 16 during a routine check in the park and was confirmed to be carrying the disease on July 23.

Called the “Black Death” in history books due to the disease ravaging the European continent during the Middle Ages. Yersina Pestis (aka Y. Pestis) also known as Plague was responsible for killing more the 25 million people.

There on on average 7 cases a year that are reported in the United States and if discovered within a timely manner can be treated with antibiotics. According to the Center Disease for Control, almost all cases have been found in the Western United States and fortunately at this time none of these cases have been fatal.

Y. Pestis, Anthrax, Botulinum, Staphylococcal enterotoxin B (SEB) and Tularemia along with Ricin Toxin among others are currently under the Dept. of Homeland Security radar since they are all good candidates for being developed into a weapon that can be used by terrorist. As a result several protocols have been put into place to rapidly detect and deter such a horrific act form happening and putting plans in to play to dramatically minimize the event should one occur.

AdVnt Biotechnologies has been helping First Responders throughout the globe by offering a reliable, rapid and portable solution to the early detection of a bio-terror event with our line of BADD Single Agent Detection Test and Pro-Strip Rapid Screening System. Thanks to advancements in the area of Immunoassay Bio-Technology, Safety Professionals responding to a Bio-Terror threat event will have the tools they need to rapidly and accurately detect if the suspected agent involved is real emergency or a badly planned hoax, allowing them to put into place all the necessary safeguards that will be needed in order to contain and control such an event.


Anthrax Vaccine for Children?

A recent article published in the Homeland Security Newswire Oct 26,2011 titled “Government considers testing anthrax vaccine on children” discusses the issues currently being considered by the US Government for inoculating children for Anthrax. While the vaccine has been administered to adults with no ill effects to date. The question about the safety of vaccinating children has raised some serious questions. How is it justifiable to vaccinate children for Anthrax with a new untested drug when there is no immediate danger of anthrax present? The more rational answer of course is it’s better to test the drug now then to wait when there is a full blown emergency and find out only then whether or not the vaccine is safe for children.

The article does not go into detail about how well the vaccine was received by the adults (mostly military personnel serving in Iraq and Afghanistan) or list any ill side-effects. Nor does the article explain where the US Government plans to locate these parents who will be willing to subject their children to a untested vaccine for a serious life threatening disease. Especially for a threat they may never come into contact with in their lifetime. Since this is an issue of proper preparedness there might be other options to consider. Companies like AdVnt Biotechnologies LLC, now provide early detection test for anthrax and now it is possible get results to show in as little as 3 to 15 minutes. Early detection of exposure will noramlly allow plenty of time for proper medical attention. But how much more prepared can we be through the use of vaccinations and more important, how safe can we make our children?

On the surface it seems that maybe the US Government is acting a bit hasty in getting this new vaccine to the general populace. It is important to remember in the framework of Domestic Preparedness, the argument can seem rational when confronted with the day to day possibility that at any time one person acting alone or in concert with others can create a bio-terror crisis by releasing weaponized anthrax or other harmful bio-agents into a heavily populated area. Therefore, being able to conceive of a plan to prepare a nation of fully vaccinated bystanders could go along way to contain the spread of such a threat if such an bio-terrorist event such as the release of anthrax were to occur. So we also have to take into consideration, what are the chances going to be of this event happening in or around our children?

To get a better understanding of this discussion, it might be a good idea to take a moment to step back and reacquaint ourselves with anthrax and why it has become one of the most notorious bad boys in the bio-threat arena. The Center of Disease Control has listed Anthrax as a class A agent meaning it poses a hazard to human health and is able to affect large population and requires a great deal of planning to control

Anthrax comes from the bacteria Bacillus anthracis and is able to spread through spore growth. Anthrax infection can be introduced through three manifestations, cutaneous (skin), inhalation, and gastrointestinal. The most common mode of Anthrax infection is cutaneous, which can enter the body though cuts or abrasions on skin. Anthrax can contaminate animal hides such as wool, hair products and leather goods from infected animals. It is also known for it’s ability to lay dormant in the ground or in the environment for extremely long periods of time. The symptoms of anthrax depends on the manner in which it is delivered to your system. If it is through the skin, symptoms include raised itchy bumps that resembles insect bites but within 1-2 days develops into a vesicle and then a painless ulcer, usually 1-3 cm in diameter, with a characteristic black necrotic (dying) area in the center accompanied by swollen Lymph glands near the adjacent area. Deaths are rare if treated with the appropriate antimicrobial therapy.

The second manifestation of anthrax is gastrointestinal and most likely to come from contaminated meat. Incidents of death through gastrointestinal contact is usually very high. Infections through gastrointestinal anthrax is an acute inflammation of the intestinal tract. Initial signs of nausea, loss of appetite, vomiting, and fever are followed by abdominal pain, vomiting of blood, and severe diarrhea. Cases of gastrointestinal anthrax is higher then skin infection.

Anthrax can also be transmitted through inhalation. This method of infection presents the most serious threat to humans. Inhalation of anthrax resembles a common cold or flu like symptoms accompanied by a sore throat, mild fever, muscle aches with weakness and lightheadedness. Because of the familiar flu like symptoms, anthrax can infections can often be overlooked as a possible cause of infection for several days until the symptoms progress to severe breathing problems and toxic shock. The inhalation of anthrax is usually fatal.

Once the forensic details of the anthrax threats are laid out, it is easy to see why the development of a anthrax vaccine and it’s application has become a matter of concern for the US Government in designing a preparedness plan in case of a bio-terrorist anthrax attack. The risk of vaccinating children with a yet unproven drug seems pale in comparison with the harsh reality of what those children could be facing should they ever come into contact with weaponized anthrax. Imagine how parents felt when confronted with the choice of inoculating their children with the then unproven polio vaccine when they were confronted with the very real possibility of seeing their children infected with polio.

If the thought of you or your children getting vaccinated may seem irrational it is important to keep in mind that this controversial topic falls within the framework of Domestic Preparedness. Since 2006 AdVnt Biotechnologies LLC has been actively on the forefront of Bio-Warfare Detection, working actively within this framework and has a proven track record of success in bio-warfare detection world wide. AdVnt Biotechnologies has been awarded with the “Support Anti-Terrorism by Fostering Effective Technologies Act of 2002 ( SAFETY ACT)“ Cerificate of Conformance and both AdVnt Biotechnologie’s BADD Anthrax Detection Test and Pro-Strip Multi-Agent Detection Test have been used around the global by first responders to rapidly detect the prescience of anthrax and other serious bio-threats targeted by bio-terrorist. Proven to reliably detect anthrax spores down to 1.55 – 1.6 x104FU/ml (Less than an infectious dose and not visible to the human eye), in as little as 15 minutes or less. AdVnt Biotechnologies rapid, reliable hand held assays have raised the bar in bio-detection standards.

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Is Al Qaeda Seeking Weapons of Mass Destruction?

By Dr. Neil Livingstone.



Reports surfaced in early January that approximately forty Al Qaeda members in Algeria died from plague after the deadly bacteria escaped from a surreptitious laboratory where they were attempting to weaponize the disease. Although there has been no official confirmation that that is exactly what happened, it is clear that something out of the ordinary did occur in Algeria at that time, and the reports are part of a mounting body of evidence, both circumstantial and confirmed, that Al Qaeda is attempting to acquire weapons of mass destruction – most likely, in this situation, a bio weapon.

It has long been an article of faith that the United States and its allies would get an early warning – through an accidental release or an outbreak of some unusual disease – about the possible misuse of bio agents. Accidental releases are not common, but they have occurred a number of times in the past – most notably in 1979 in the region around a Soviet biological weapons facility in Sverdlovsk, where there was an accidental anthrax release that killed 68 people. The Soviets, of course, denied not only that anthrax had caused the fatalities but also that the facility was engaged in the production of biological weapons – in contravention of the Biological Weapons Convention. The incident remained a matter of controversy during the Reagan administration, but after the fall of the Soviet Union the Russians ultimately acknowledged what happened.

After the 9/11 terrorist attacks in 2001, the U.S. intelligence community found substantial evidence, in Afghanistan and elsewhere, that Al Qaeda was indeed working on acquiring biological weapons – and, according to the 9/11 Commission, the effort was more advanced than previously believed. Although Al Qaeda had investigated the possible use of other dangerous agents, including plague and even ebola, its more immediate goal seemed to be to create a fully stable and weaponized strain of anthrax.

Ebola, however, is a hemorrhagic fever and one of the deadliest diseases in the world – also one of the most contagious. The good news is that there is no known incidence of it being successfully weaponized, and many experts believe that, because it outruns its hosts so quickly, it also dissipates quickly and therefore does not expand beyond a certain critical mass. The Japanese Am Shinrikyo cult – which carried out the 1995 Tokyo subway attack using Sarin (a G Series nerve agent) – tried to acquire an ebola culture but ultimately gave up and moved onto more conventional bio agents.
Weaponized anthrax also represents a formidable scientific challenge, so it is not surprising that Al Qaeda may have focused on plague – most likely bubonic plague, which was known as the “Black Death” in the Middle Ages, is considerably easier to develop, and can be created in a modest laboratory with commercially available equipment. Plague is still a problem in Africa, so it would not have been too difficult for Al Qaeda to have acquired a sample culture. Plague also would require less scientific expertise than trying to create weaponized anthrax or smallpox.

In that context, it should be remembered that Ayman al-Zawahiri (Al Qaeda’s number-two man after Osama bin Laden) is not only a trained medical doctor with a master’s degree in surgery, but also the son of a pharmacologist and a chemistry professor. In addition, he is known to have had an interest in biowarfare – and, interestingly, spent time in Russia in the 1990s. According to the former Russian spy Alexander Litvinenko, al-Zawahiri received training from the FSB, the successor organization to the KGB, and was the FSB’s principal connection to Al Qaeda. Litvinenko, of course, became internationally famous, belatedly, when he was murdered by a dose of plononium-210, an extremely rare and costly radiological agent that, it is believed, had been slipped into his food in a Soho sushi restaurant in London.

Plague is disseminated via a “vector,” most commonly an infected flea carried by a rat, which is known as the reservoir host. Traditionally, the best way of controlling the plague has been the creation and implementation of effective rodent-management programs. Largely for that reason, most Western countries are believed to be – thanks to their modern hygiene standards and medical facilities – far less at risk from plague than are the so-called “lesser developed” countries of Africa, Asia, and Latin America.
In addition to hard drives, floppy discs, and material gleaned from interrogations, the United States has accumulated a great deal of evidence related to Al Qaeda’s continuing, and apparently increasing, interest not only in bio weapons, but also in chemical and radiological weapons (especially RDDs, better known as Radiological Dispersion Devices – i.e., “dirty bombs”). Among the more substantive evidence confirming this theory are some NBC (nuclear, biological, and chemical) protective suits seized by British police during a raid on a Finsbury Park mosque in 2003. In addition, Jordanian authorities claimed to have thwarted a major chemical attack in 2004, and there have been credible reports that Abu Musab Zarqawi, Al Qaeda’s late leader in Iraq, had managed to acquire or develop ricin, one of the three deadliest substances on earth (the others being plutonium and botulinal toxin).

Although difficult to deliver to a widely dispersed group of human targets, ricin, a derivative of the lowly castor bean, is an excellent assassination weapon and may have been used by the Soviets to murder several heads of state and other leading Third World politicians. Another telling clue is that Al Qaeda in Iraq hired two chemists in 2004 and tasked them with trying to develop crude chemical and biological weapons. Fortunately, U.S. Marines discovered their laboratory (in Falluja) before any weapons had been manufactured. The Marines did find materials, however, that could have been used to make hydrogen cyanide. Other U.S. troops discovered caged dogs and other animals that they believed were going to be used by Al Qaeda as “guinea pigs” to test either chemical or biological weapons.
Jihadists believe that Muslims have a religious duty to wage an “offensive jihad” against infidels, and there seems to have been no lessening of Muslim antipathy toward the West in recent years. Many observers believe, in fact, that the threat of a Jihadist attack employing weapons of mass destruction (WMDs) is growing rather than receding, despite the recent presidential election in the United States and the dramatic growth of homeland-security precautions against terrorism. Former U.S. Senator Sam Nunn (D-Ga.) said even prior to 9/11 that the possibility of a terrorist WMD attack against the United States is no longer a question of “if” but “when” such an attack might occur.

Nunn’s statement was echoed by former Vice President Dick Cheney in an interview two weeks after leaving office. According to Cheney, there is a “high probability” of a nuclear or biological attack against the United States within the next few years. That chilling possibility is backed up by a study cited by Gary Ackerman, research director of the National Consortium for the Study of Terrorism and Responses to Terrorism, in which respondents indicated that they believe there is a thirty percent probability of a WMD attack against the United States within the next five years.

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